Integrate
Cross-link MPstruc, RCSB PDB, OPM, and UniProt records while preserving source-specific provenance.
Membrane-protein reconciliation platform
MetaMP brings fragmented membrane-protein evidence into one traceable workspace.
MetaMP integrates metadata from MPstruc, RCSB PDB, OPM, and UniProt; surfaces cross-source disagreement; and supports topology benchmarking, single-record inspection, and deployment-ready review workflows.
4,089
harmonised structures
121
expert-reviewed conflicts
4
primary source systems
MPstruc
RCSB PDB
OPM
UniProt
Discrepancy review
A clean workflow for fragmented membrane-protein evidence.
MetaMP is designed around the practical review sequence: bring sources together, expose disagreement, inspect records, and export evidence for review.
Compare
Surface broad-group, topology, boundary, and metadata differences instead of hiding them in a single consensus label.
Inspect
Review individual membrane-protein entries with structure, topology calls, evidence sources, and subunit-level context.
Benchmark
Use expert-reviewed contested records and export-ready outputs to support reproducible model and curation assessment.
What the current MetaMP implementation demonstrates.
This page summarizes the platform functions that have been implemented, revised, and prepared for stakeholder review.
P
Provenance-aware integration
Cross-links membrane-protein metadata across MPstruc, RCSB PDB, OPM, and UniProt while preserving source-specific context.
D
Discrepancy views
Surfaces cross-source disagreement over time and links chart selection to detailed record-level review tables.
T
Topology comparison
Compares expert, OPM, TMDET, DeepTMHMM, TMbed, and TMAlphaFold-linked predictor signals in one record view.
M
Assistive modelling
Provides broad-group classification and transmembrane-segment benchmarking as reproducible baselines, not as autonomous curation.
Q
Quality-control workflows
Flags accession replacements, unusual resolution values, inconsistent labels, and records requiring contextual interpretation.
E
Export-ready outputs
Supports stakeholder-facing image/PDF/SVG export workflows for figures, manuscript review, and deployment demonstrations.
Application views that demonstrate the working MetaMP platform.
The dashboard is shown as the primary product view; the supporting route cards summarize the other cached screens stakeholders can inspect without running the backend.
Dashboard analytics
Integrated metadata summaries, platform-level statistics, and high-level database coverage in the main analytics workspace.
Welcome page
Introduces MetaMP and routes users toward exploration, database review, and use-case workflows.
About MetaMP
Explains resource scope, source databases, and the scientific motivation for reconciliation.
Searchable database
Lets users inspect harmonised entries and filter metadata fields across integrated sources.
Discrepancy review
Shows cross-source disagreement and links aggregate trends to record-level evidence.
Run the published MetaMP stack locally.
Reviewers and collaborators can clone the repository and launch the full published app with one command.
Quick Start
git clone https://github.com/Ebenco36/MetaMP-Server.git && cd MetaMP-Server && ./scripts/metamp-reviewer-start.sh
Case study: single-record evidence view.
PDB accession 7RSL demonstrates how MetaMP combines 3D structure, preferred membrane call, topology tracks, and subunit boundaries in one reviewable record.
Publication
MetaMP is described in the following peer-reviewed article. Please cite this work if you use the platform or benchmark in your research.
Awotoro E et al. MetaMP: a membrane-protein reconciliation and benchmarking platform. Computational and Structural Biotechnology Journal, 2026. https://doi.org/10.34133/csbj.0165
BibTeX
@article{awotoro2026metamp,
title = {MetaMP: a membrane-protein reconciliation and benchmarking platform},
author = {Awotoro, Ebenezer and others},
journal = {Computational and Structural Biotechnology Journal},
year = {2026},
doi = {10.34133/csbj.0165},
url = {https://doi.org/10.34133/csbj.0165}
}Deployment-oriented architecture.
The full platform combines backend services, data ingestion, harmonisation, and an interactive frontend. This static page is only the public demonstration layer.
